Prevention Matters

Twenty-two institutions across the country are participating in a Phase III clinical trial to determine whether a new investigational "nicotine vaccine" is safe, effective and capable of stimulating an immune response. Approximately 1,000 male and female smokers aged 18 to 65 will take part in the 12-month study NicVAX, a vaccine developed by Nabi Biopharmaceuticals.

Nicotine molecules are so small that they can pass through the body's brain/blood barrier without triggering a reaction from the immune system. However, NicVAX stimulates the immune system to produce antibodies that bind to or capture nicotine
molecules in the bloodstream, making them too large to cross the blood-brain barrier. As a result, many of the expected rewards from smoking are blocked, making it easier for the smoker to become and remain abstinent.

“Smokers continue to smoke even when they know it’s harmful because of these ‘brain effects,’” explained David Gonzales, Ph.D., principal investigator and clinical investigator in medicine at the Oregon Health and Science University, one of the 22 test centers. “While a smoking cessation medication such as varenicline prevents nicotine from binding to receptors once it is in the brain, NicVAX is designed to block nicotine before it enters the brain.”

As Congress deliberated on an economic stimulus plan, an AIDS worker on the other side of the country eloquently voiced the questions that are on the minds of public health officials everywhere.

"Are positions building highways of more importance than positions promoting good health?" Michael Kaplan, executive director at Cascade AIDS Project in Oregon, asked in a guest column that appeared in today's edition of "The Stump," a blog produced by The (Portland) Oregonian's Editorial Board. "Does a salaried construction worker spend less in our communities than a salaried public health specialist? Are positions focused on green energy -- efforts that save on fuel costs in the long run -- of more value than positions focused on health promotion that save on health care costs in the long run?

"The reality is that some members of Congress have decided which sectors of society they care for more, and it seems those who serve private interests over the public good are winning," Kaplan said. "At a time when the economy will only further decimate the public health system -- a system already ailing -- how is it we can say there is no need to support the return of jobs to help with this important work for our community?"